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sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">缁撴灉鏄剧ず锛屽湪涓烘湡 16 鍛ㄧ殑鏍稿績娌荤枟鏈熷悗锛岄瞾鍏硅闆烽挔鐗囩粍 39.7% 鐨勬偅鑰呮渶鍚庝袱娆 sUA 姘村钩鈮?60 渭mol/L锛堜复搴婅揪鏍囬槇鍊硷級锛屾樉钁楅珮浜庡鐓х粍鐨 26.5%銆傜 16 鍛ㄦ椂 sUA鈮?60 渭mol/L 鐨勬偅鑰呮瘮渚嬪湪椴佸吂璇洪浄閽犵墖缁勬洿楂橈紙52.6% vs. 34.5%锛涘崟渚 p<0.0001锛夛紝涓旂枟鏁堜紭鍔垮湪 52 鍛ㄧ殑鎵╁睍娌荤枟鏈熶腑鎸佺画淇濇寔銆傚畨鍏ㄦ€ф柟闈紝椴佸吂璇洪浄閽犵墖缁勪笌瀵圭収缁勬不鐤楃浉鍏充笉鑹簨浠跺彂鐢熺巼鐩歌繎锛屽涓鸿交搴︽垨涓害銆侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">鍙﹀锛屽浗鍐呬竴鍝佺孩鐨勬皹娉婃浛璇洪浄锛圓R882锛夈€佺拵榛庤嵂涓氱殑 Puliginurad 鐮斿彂杩涘害涔熷浜庡叏鐞冪涓€姊槦锛屽潎鎺ㄨ繘鍒颁簡 III 鏈熶复搴婇樁娈点€傚挨鍏跺€煎緱鍏虫敞鐨勬槸 AR882锛屼粠浠婂勾 6 鏈堟姭闇茬殑 II 鏈熶复搴婃暟鎹潵鐪嬶紝璇ヤ骇鍝佷笉浠呭彲浠ユ湁鏁堥檷浣庡翱閰告按骞筹紝杩樺睍鐜板嚭鎸佺画婧惰В鐥涢鐭崇殑娼滃姏锛屽叿鏈夊樊寮傚寲绔炰簤浼樺娍銆侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">娴峰垱鑽笟銆佹柊鍏冪礌鑽笟銆佷俊璇虹淮鍖昏嵂 URAT1 鎶戝埗鍓傜揣闅忓叾鍚庯紝鐩墠姝ｅ湪寮€灞 II/III 鏈熶复搴婄爺绌躲€傛€讳箣锛屽浗浜ф柊鍨 URAT1 鎶戝埗鍓傚凡缁忚搫鍔垮緟鍙戙€侟/span><br> </p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="color:rgb(192,0,0);font-family:鐎瑰缍? SimSun;"><strong>鍙岄澏鐐瑰拰灏忔牳閰歌繛鐣櫥鍦裹/strong></span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">闄や簡 URAT1 鎶戝埗鍓傦紝鍙岄澏鐐广€佸崟鎶椼€佸皬鏍搁吀绛夊垱鏂扮枟娉曚篃闄嗙画鐧讳笂浜嗙珵鎶€鑸炲彴锛屾垚涓哄叏鐞冭嵂浼佽閫愮棝椋庡競鍦虹殑鎴樼暐楂樺湴銆傝繖浜涜嵂鐗╅拡瀵圭棝椋庡鏉傜殑鐥呯悊鏈哄埗灞曞紑澶氱淮搴︾獊鐮达紝鏃㈠欢缁簡瀵瑰翱閰镐唬璋㈢殑娣卞害骞查锛屽張鍦ㄧ値鐥囨帶鍒躲€侀暱鏁堢鐞嗙瓑缁村害寮€杈熶簡鏂拌矾寰勶紝鍥藉唴浼佷笟鏇存槸鍦ㄥ涓粏鍒嗛鍩熷睍鐜板嚭棰嗚窇娼滃姏銆侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">鍦ㄥ弻闈剁偣鎶戝埗鍓傞鍩燂紝閫氬寲涓滃疂鐨 THDBH151 鐗囨槸鍥藉唴杩涘睍鏈€蹇殑銆傝浜у搧涓€鏂归潰鎶戝埗榛勫槍鍛ゆ哀鍖栭叾锛圶O锛夛紝浠庢簮澶翠笂鍑忓皯灏块吀鐨勭敓鎴愶紝鍙︿竴鏂归潰鎶戝埗鑲惧皬绠 URAT1 杞繍浣撳灏块吀鐨勯噸鍚告敹锛屽姞蹇翱閰告帓闄や綋澶栵紝鐩墠姝ｅ湪寮€灞 II 鏈熶复搴婄爺绌躲€侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">浠婂勾 5 鏈堬紝閫氬寲涓滃疂鍏竷浜 THDBH151 鍦ㄧ棝椋庢偅鑰呬腑鐨 IIa 鏈熸暟鎹€傜敤鑽4鍛紝璇ヤ骇鍝 150mg 琛€灏块吀姘村钩杈冨熀绾夸笅闄嶆瘮渚嬨€佲墹6mg/dL 鍜鈮?mg/dL 鐨勮揪鏍囩巼鍧囦笌闈炲竷鍙镐粬涓村簥鏈€楂樺墏閲 80mg 鎺ヨ繎锛岀 28 澶╃粰鑽悗 0-24h 骞冲潎琛€灏块吀姘村钩杈冨熀绾跨殑涓嬮檷姣斾緥楂樹簬闈炲竷鍙镐粬 80mg锛?9.3% vs 43.4%锛夈€傚畨鍏ㄦ€ф柟闈紝鎬讳綋涓嶈壇浜嬩欢鍙嶅簲鐜囦笌瀹夋叞鍓傜浉杩戯紝娌℃湁娌荤枟鐩稿叧涓ラ噸涓嶈壇鍙嶅簲鎶ュ憡銆侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">鍗曟姉闃佃惀涓紝閽堝 IL-1尾闈剁偣鐨勭爺鍙戝挨涓烘椿璺冿紝杩欎竴闈剁偣鍥犺兘绮惧噯闃绘柇灏块吀鐩愭櫠浣撳紩鍙戠殑鐐庣棁绾ц仈鍙嶅簲锛屾垚涓烘帶鍒剁棝椋庢€ユ€у彂浣滀笌棰勯槻澶嶅彂鐨勫叧閿獊鐮村彛銆傚浗鍐呬紒涓氬湪杩欎竴棰嗗煙宸茬粡灞曠幇鍑轰簡寮哄姴鐨勭垎鍙戝姏锛氶暱鏄ラ噾璧涘紑鍙戠殑浼忔濂囨嫓鍗曟姉鐜囧厛鎾炵嚎锛屼笁鐢熷浗鍋ョ殑 SSGJ-613 绱ч殢鍏跺悗锛屼篃宸查€掍氦浜嗕笂甯傜敵璇枫€侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:1.75em;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:2em;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><span style="font-family:瀹嬩綋, SimSun;">浼忔濂囨嫓鍗曟姉閫氳繃绮惧噯闃绘柇 IL-1尾淇″彿閫氳矾锛屼粠鏍规簮涓婃姂鍒剁値鐥囧弽搴斻€傗參鏈熶复搴婄爺绌剁粨鏋滄樉绀猴紝璇ヤ骇鍝佸崟娆＄粰鑽悗鍗冲彲蹇€熻捣鏁堬紝6-72 灏忔椂闀囩棝鏁堟灉涓庢縺绱犵浉褰擄紝6 涓湀鍐呴娆″鍙戦闄╅檷浣 87%锛屼笖鏈彂鐜颁笌鑽墿鐩稿叧鐨勪弗閲嶄笉鑹弽搴斻€侟/span></p><p style="-webkit-text-stroke-width:0px;color:rgb(44, 62, 80);font-family:Avenir, Helvetica, Arial, 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